A computer model of kidney function that includes how hormones affect kidney tubes and blood vessels can accurately simulate how the kidneys control salt and water levels in the body.
Scientific Claim
A lumped-nephron mathematical model explicitly represents physiological features and incorporates hormonal regulatory effects on tubular and vascular function to accurately simulate renal salt and water excretion regulation.
Original Statement
“We present a lumped-nephron model that explicitly represents the main features of the underlying physiology, incorporating the major hormonal regulatory effects on both tubular and vascular function, and that accurately simulates hormonal regulation of renal salt and water excretion.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim accurately describes the model's design as stated in the abstract without overstatement.
Evidence from Studies
Supporting (1)
Hormonal regulation of salt and water excretion: a mathematical model of whole kidney function and pressure natriuresis.