A hop extract makes certain gut cells release hormones that make you feel full and reduces the hormone that makes you feel hungry, by activating special taste receptors in the gut.
Scientific Claim
A hydroalcoholic extract from Humulus lupulus L. inflorescences stimulates the secretion of glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) while reducing ghrelin levels in STC-1 intestinal secretin tumor cells, mediated by bitter taste receptors Tas2r138 and Tas2r120 and calcium-dependent signaling pathways.
Original Statement
“The results demonstrate that the hop extract is a rich source of bitter compounds (mainly α‐, β‐acids) that stimulate the secretion of anorexigenic peptides (glucagon‐like peptide 1 [GLP‐1], cholecystokinin [CCK]) in a calcium‐dependent manner while reducing levels of hunger‐related hormones like ghrelin.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Based on abstract only - full methodology not available to verify. The study is an in vitro cell line experiment with no causal inference possible beyond observed associations. 'Stimulates' and 'reducing' imply direct causation, which cannot be confirmed without full experimental controls.
More Accurate Statement
“A hydroalcoholic extract from Humulus lupulus L. inflorescences is associated with increased secretion of glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) and reduced ghrelin levels in STC-1 intestinal secretin tumor cells, potentially mediated by bitter taste receptors Tas2r138 and Tas2r120 and calcium-dependent signaling pathways.”
Evidence from Studies
Supporting (1)
This study found that hop extract makes gut cells release hormones that make you feel full and reduces the hunger hormone, and it works through specific bitter-taste sensors and calcium signals in the cells.