A nutrition bar with 11 grams of protein and 2 grams of leucine peptide produces the same level of fullness after eating as a bar with 13 grams of protein and 3 grams of leucine peptide in healthy...

Pro

Against

Mechanism

Synthesis from 1 study

How it works

Leucine in the bar triggers the gut to send a fullness signal to the brain, making people feel satisfied even when there is less protein. Two grams of leucine is enough to trigger this signal fully, so adding more leucine doesn't make people feel any fuller.

Most probable mechanism

In Simple Terms

When leucine from the nutrition bar enters the bloodstream, it signals the gut to release hormones that tell the brain to stop feeling hungry, making a person feel full even with less protein.

Causal chain

Leucine peptide is digested and absorbed, increasing plasma leucine concentration in a dose-dependent manner

Verified by multiple studies

which leads to

Elevated plasma leucine activates nutrient-sensing receptors on enteroendocrine L-cells in the intestinal lining, triggering secretion of satiety hormones

Indirect evidence only

which leads to

Satiety hormones circulate to the brainstem and hypothalamus, where they bind to receptors that suppress activity in hunger-promoting neurons

Supported by evidence

which leads to

Neural signaling reduces subjective appetite sensations including hunger, desire to eat, and prospective food consumption

Verified by multiple studies

Evidence from Studies

Supporting (1)

Community contributions welcome

Consuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women.

Randomized Controlled Trial

Human

2018 May 1

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Consuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women.

Score: 59

DOI: 10.1093/jn/nxy023

Similar Assertions

In healthy women, consuming a 3-gram leucine peptide supplement does not reduce hunger or desire to eat more than a control bar, even though it raises blood leucine levels more than a 2-gram dose, showing that higher leucine levels do not proportionally reduce appetite.

83%

In healthy women aged approximately 28 years, a 180-kcal nutrition bar with 2 grams of added leucine peptide increases feelings of fullness after eating and reduces the desire to eat more later, compared to a similar bar without leucine, even when both bars have the same calories and protein.

80%

When healthy women eat nutrition bars with 0, 2, or 3 grams of added leucine peptide, their blood leucine levels rise proportionally to the dose, but their feelings of fullness and peptide YY levels do not change in a corresponding way.

78%

Consuming a nutrition bar with 3 grams of leucine peptide raises plasma leucine levels by 260% compared to a bar with no leucine peptide in healthy women, but does not increase feelings of fullness.

77%

In healthy women, consuming 2 or 3 grams of leucine peptide does not change levels of the gut hormone PYY after eating, compared to a control bar.

76%