A protein called LAMP2A, which is involved in cellular cleanup processes, was found at similar levels in people having a heart attack and those with stable heart disease, and its levels didn't relate to PLIN2 protein levels.
Scientific Claim
Lysosome-associated membrane protein 2A (LAMP2A) expression, a key component of chaperone-mediated autophagy, showed no significant difference between ST-elevation myocardial infarction (STEMI) and chronic coronary syndrome (CCS) patients (STEMI vs. CCS 1.960 (1.490–2.880) vs. 2.025 (1.410–2.423); p = n.s.) and was not correlated with perilipin-2 (PLIN2) protein expression.
Original Statement
“LAMP2A was not different in the two groups [STEMI vs. CCS 1.960 (1.490–2.880) vs. 2.025 (1.410–2.423); p = n.s.] and was not correlated with PLIN2 protein expression (p = n.s.) (Figure 3A,B).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study is observational and reports no significant difference and no correlation between variables. The claim appropriately states these findings without implying causation.