In women with fibromyalgia, a 15-minute session of moderate exercise raises levels of IGF-1 and IGFBP-3 in the blood without changing markers of inflammation like CRP or IL-8, suggesting these hormonal changes happen without involvement of inflammatory processes.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

40

Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia

Randomized Controlled Trial

Human

2017 Jan 25

A short 15-minute bike ride made women with fibromyalgia produce more IGF-1 and IGFBP-3, just like healthy women—without any signs that inflammation was involved. This means exercise can boost these helpful proteins even when you’re in pain, and it’s not because inflammation went down.

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Source Study

Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia

Score: 40

DOI: 10.1186/s12891-017-1402-y

Similar Assertions

Women with fibromyalgia show the same short-term rise in two specific blood proteins (IGF-1 and IGFBP-3) during exercise as healthy women, even though they exercise at lower intensities.

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In women with fibromyalgia and healthy women, a 15-minute session of moderate or high-intensity cycling raises IGF-1 levels in the blood by a similar amount, regardless of how much body fat they have.

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86%

A 15-minute moderate cycling workout raises levels of insulin-like growth factor-1 (IGF-1) in the blood by about 11 ng/mL in women with fibromyalgia, and the increase is similar to that seen in women without fibromyalgia.

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84%

Women with fibromyalgia report more pain and fatigue during intense exercise than women without the condition, even though both groups show similar rises in a blood protein called IGF-1, suggesting that how the body responds chemically doesn't always match how much discomfort a person feels.

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84%