correlational
Analysis v1
33
0
Adding more MOTS-c to pancreatic cells reduces genes involved in glutamine processing.
Scientific Claim
MOTS-c overexpression in Min6 cells is associated with reduced expression of glutaminolysis-related genes Slc1a5, Gls1, and Gls2.
Original Statement
“MOTS-c overexpression in Min6 cells were able to lower these glutaminolysis-related genes (Fig. 5f).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study used 'lowered' which implies causation, but the design lacks randomization/blinding confirmation. Corrected to 'associated with' to reflect observational association.
Evidence from Studies
Supporting (1)
33
33
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes
Randomized Controlled Trial
Human
2025 AugContradicting (0)
0
No contradicting evidence found