After losing weight, muscles get better at using sugar not because they make more GLUT4 proteins, but because the existing proteins move to the right place or work better.

40

Pro

0

Against

Evidence from Studies

Supporting (1)

40

Community contributions welcome

40

Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.

Cohort Study

Human

1992 Feb

After losing weight, the muscles of obese people got better at using insulin to take in sugar, but they didn’t make more of the sugar-carrying protein (GLUT4). That means the protein must have been working better or moving to the right place, not just being made in bigger amounts.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss. Effect on muscle glucose transport and glucose transporter GLUT4.

Score: 40

DOI: 10.1172/JCI115638

Similar Assertions

Even people with type 2 diabetes can see their muscles start working like healthy muscles again after losing a lot of weight — and it’s not because they make more sugar transporters, but because the ones they have work better.

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