mechanistic
Analysis v1
After sun damage, the skin’s immune system gets stuck in 'alarm mode' — releasing chemicals like NF-κB and COX-2 that help tumors grow instead of stopping them.
Evidence from Studies
Supporting (0)
0
Community contributions welcome
No supporting evidence found
Contradicting (1)
0
Community contributions welcome
1
Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective
Narrative Review
2021The study says sun exposure causes skin cancer and that inflammation plays a part, but it never checks the three specific body chemicals (NF-κB, HMGB1, COX-2) mentioned in the claim, so we can't say for sure they're involved.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.