As people get older, a key protein called SIRT1 becomes less active, which means it can't help another protein (eNOS) do its job properly—so the body makes less nitric oxide, and blood vessels don't work as well.

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An Overview of NO Signaling Pathways in Aging

Narrative Review

2021 Jul 27

The study shows that as people age, their bodies make less nitric oxide, which is important for blood vessel health. The claim says this happens because a protein called SIRT1 slows down with age, which in turn reduces nitric oxide. Even though the study didn’t check SIRT1, it confirms the nitric oxide drop happens with age — which matches the claim’s main point.

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Source Study

An Overview of NO Signaling Pathways in Aging

Score: 1

DOI: 10.3390/molecules26154533

Similar Assertions

As people get older, their blood vessels have a harder time relaxing because they produce less of a helpful chemical called nitric oxide, which makes it tougher for blood to flow freely — this is one reason why older adults are more likely to have heart and blood vessel problems.

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