Atorvastatin blocks a signal (ANGPT2) that makes blood vessels leaky, helping them stay strong and sealed by turning on a repair signal (Tie2) in the vessel lining.

15

Pro

0

Against

Evidence from Studies

Supporting (1)

15

Community contributions welcome

15

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

Randomized Controlled Trial

Animal

2021 Aug

The study found that atorvastatin, a cholesterol drug, helps stabilize blood vessels by reducing a protein (ANGPT2) that makes vessels leaky and unstable — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization

Score: 15

DOI: 10.1007/s10456-021-09767-9

Similar Assertions

Atorvastatin helps keep the glue between blood vessel cells tight by stopping a chemical signal that makes the glue fall apart, which helps stop leaks in artery plaques.

15

0

80%

Atorvastatin helps make the new blood vessels inside artery plaques less leaky by helping support cells stick better and sealing gaps between vessel lining cells, which may stop bleeding inside the plaque.

15

0

78%

A common cholesterol drug called atorvastatin can reduce the growth of leaky new blood vessels inside artery plaques, even when it doesn’t lower cholesterol much—this might help prevent plaques from bursting.

15

0

72%

Atorvastatin helps the support cells (pericytes) wrap around new blood vessels in plaques more tightly, making them stronger and less likely to leak.

15

0

72%