Between 2001 and 2018, rates of breast, colorectal, and uterine cancers rose significantly among U.S. women aged 20 to 49, with the fastest increases occurring in women under 30, especially White women aged 20–24 for colorectal cancer and Hispanic women aged 25–29 for uterine cancer.

Between 2001 and 2020, the number of new cases of colorectal cancer in adults aged 20 to 54 rose in every region of the United States, with the fastest increase in the West and the slowest in the South, showing that different areas experienced different rates of growth in this disease.

In the United States, men between the ages of 25 and 44 died from early-onset colorectal cancer at a higher rate than women in 2020, with 2.6 deaths per 10,000 men compared to 2.0 per 10,000 women.

Since 2013, the number of new colorectal cancer cases per year has risen by 3% each year among U.S. adults aged 20 to 49, while cases have decreased in older adults.

Between the early 1990s and 2018, the number of new colorectal cancer cases in people under 50 in the U.S. rose by nearly 50%, from 8.6 to 12.9 cases per 100,000 people, and similar increases have been seen in other countries, suggesting a growing trend not explained by older populations.

From 2001 to 2020, colorectal cancer became more common in younger adults in every part of the U.S., and men were diagnosed at higher rates than women, with their rates rising faster over time.