Oleuropein aglycone triggers a cellular cleanup process called autophagy in human neuroblastoma cells, and part of this effect requires AMPK activity. When AMPK is blocked, autophagy decreases but still occurs, suggesting other pathways besides AMPK are also involved.

In human neuroblastoma cells, blocking AMPK with compound C decreases autophagy triggered by oleuropein aglycone, but does not stop it completely, suggesting other pathways besides AMPK also contribute to this process.

Oleuropein aglycone, a compound found in olive plants, triggers a cellular cleanup process called autophagy in human cancer cells and mouse brain tissue by altering specific signaling molecules that regulate this process.

Oleuropein aglycone, a compound found in olives, triggers a sequence of molecular events in human nerve cancer cells and mouse brain tissue that leads to the formation of cellular structures involved in recycling damaged components. This process is associated with changes in calcium levels and specific protein modifications.

In human neuroblastoma cells, a compound called oleuropein aglycone at a concentration of 50 μM triggers two distinct increases in calcium levels inside the cell, originating from the endoplasmic reticulum, and these calcium changes are necessary to activate AMPK and start the process of autophagy.

Blocking the CAMKKβ protein stops oleuropein aglycone from activating AMPK and triggering autophagy in human neuroblastoma cells, showing that CAMKKβ is required for this biological process to occur.