Doing more weight training raises levels of a protein called Frizzled-1 in older people’s muscles, no matter whether they gain muscle or not.
Scientific Claim
Higher resistance training volume increases total protein expression of Frizzled-1 in older adults, regardless of their hypertrophy response category.
Original Statement
“Higher RT volume, regardless of responsiveness groups, was followed by increased Frizzled-1 protein expression.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
probability
Can suggest probability/likelihood
Assessment Explanation
The within-subject design supports causal inference, but without blinding confirmation, probabilistic language is warranted. 'Increased' is acceptable as a probability verb.
More Accurate Statement
“Higher resistance training volume may increase total protein expression of Frizzled-1 in older adults, regardless of their hypertrophy response category.”
Evidence from Studies
Supporting (1)
Molecular signatures underlying heterogenous hypertrophy responsiveness to resistance training in older men and women: a within-subject design.
Even if older people didn’t get bigger muscles from lifting weights, doing more sets still raised a specific protein called Frizzled-1 in their muscles — no matter how much they grew.