When people with obesity do a single session of moderate-intensity cardio, their blood levels of IGF-1 and IGFBP-3 do not rise, unlike in lean individuals, suggesting the liver of people with obesity responds less to exercise in terms of producing these growth-related proteins.

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Evidence from Studies

Supporting (1)

38

Community contributions welcome

38

Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise

Cross-Sectional Study

Human

2025 Jun

In people with obesity, a single workout at moderate intensity doesn’t raise certain growth-related proteins in the blood like it does in lean people, suggesting their bodies don’t respond as well to exercise for muscle growth signals. But the active part of the growth signal stays the same, so it’s not completely broken—just slower to respond.

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No contradicting evidence found

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Source Study

Humans with obesity exhibit impaired circulating total, but not free, IGF‐1 response to acute endurance exercise

Score: 38

DOI: 10.14814/phy2.70436

Similar Assertions

In adults with obesity, endurance exercise leads to a simultaneous decrease in two related proteins, IGF-1 and IGFBP-3, which may reflect a liver-controlled process that keeps a specific form of IGF-1 at stable levels, possibly to adjust to metabolic changes.

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86%

Adults with obesity have a smaller increase in growth hormone after short bouts of endurance exercise than lean adults, and this may be linked to lower production of IGF-1 and IGFBP-3 by the liver.

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86%

During short bouts of endurance exercise, people with obesity maintain the same levels of bioactive IGF-1 in their blood as lean individuals, even though overall IGF-1 and its binding protein increase less than in lean people.

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84%

In adults with obesity, changes in IGF-1 levels during endurance exercise are not related to the degree of insulin resistance, suggesting that insulin resistance does not directly control how IGF-1 responds to this type of physical activity.

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75%