Eating earlier in the day for 4 days increased the activity of two genes related to cellular repair and longevity in the morning for overweight people compared to eating throughout the day.
Scientific Claim
Early time-restricted feeding increased morning SIRT1 gene expression by 10% and LC3A gene expression by 22% in overweight adults after 4 days of intervention compared to a control schedule.
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
This is a randomized controlled trial with direct measurements of gene expression. The verb 'increased' is appropriate for these specific short-term effects.
Source Excerpt
“eTRF also increased levels of SIRT1 (10 ± 3%; p = 0.004) and LC3A (22 ± 5%; p = 0.001) in the morning and increased levels of MTOR (9 ± 3%; p = 0.007) in the evening.”
Evidence from Studies
Supporting Evidence (1)
The study measured gene expression of SIRT1 and LC3A in the morning and found statistically significant increases with eTRF. These genes are associated with cellular repair and autophagy processes.
Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans