Eating earlier in the day for 4 days increased the activity of two genes related to cellular repair and longevity in the morning for overweight people compared to eating throughout the day.
Scientific Claim
Early time-restricted feeding increased morning SIRT1 gene expression by 10% and LC3A gene expression by 22% in overweight adults after 4 days of intervention compared to a control schedule.
Original Statement
“eTRF also increased levels of SIRT1 (10 ± 3%; p = 0.004) and LC3A (22 ± 5%; p = 0.001) in the morning and increased levels of MTOR (9 ± 3%; p = 0.007) in the evening.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
This is a randomized controlled trial with direct measurements of gene expression. The verb 'increased' is appropriate for these specific short-term effects.
Evidence from Studies
Supporting (1)
Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans