Even if you don’t have diabetes, if you’re overweight and have heart disease, a weekly shot of semaglutide can cut your risk of heart attack or stroke by 1 in 5 — and this benefit starts before you...

In adults over 45 with heart disease and obesity but no diabetes, a weekly injection of semaglutide at 2.4 mg for about 3.3 years lowers the combined risk of heart-related death, heart attack, or stroke compared to a placebo.

If you're obese and have heart disease but not diabetes, taking semaglutide might lower your chances of having a serious heart problem by 20%.

In obese adults with existing heart disease but no diabetes, a weekly injection of semaglutide at 2.4 mg is associated with a lower rate of serious heart-related events such as heart attack or stroke.

A weekly injection of semaglutide (2.4 mg) helps lower the risk of serious heart problems like heart attack, stroke, or heart-related death by 20% in people over 45 who have heart disease and are overweight, but don’t have diabetes, compared to a fake treatment.

Taking a weekly semaglutide shot (2.4 mg) for about a year and a half can help lower blood pressure, blood sugar, bad cholesterol, and body-wide inflammation in adults with extra weight but no diabetes—better than a placebo.