Even when methylene blue was given with another drug called lithium, it still didn’t help the ALS mice live longer or move better.
Scientific Claim
Combining methylene blue with lithium provided no additional benefit in SOD1(G93A) mice compared to methylene blue alone.
Original Statement
“A combination of MB with lithium also failed to provide benefits in SOD1(G93A) mice.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The phrase 'failed to provide benefits' implies causation without confirmed experimental design. Only a neutral, descriptive statement is supported by the abstract.
More Accurate Statement
“In SOD1(G93A) transgenic mice, combining methylene blue with lithium was not associated with additional benefits compared to methylene blue alone.”
Evidence from Studies
Supporting (1)
Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models
Scientists tested if adding lithium to methylene blue helped sick mice with a form of ALS, but it didn’t help at all — even methylene blue alone didn’t help. So, combining them didn’t make things better.