People exposed to picloram may develop colorectal cancer at a younger age, and this link is not simply because they are younger; it is tied to a specific biological pattern in the tumors called the SBS1 mutational signature.

People exposed to the herbicide picloram have a higher statistical likelihood of developing colorectal cancer before age 50 compared to those who develop it after age 70, based on patterns of DNA methylation observed in patient samples.

People exposed to the herbicide picloram may show distinct patterns of DNA methylation in colorectal tumors that develop at an early age.

People born after 1950 have a higher risk of developing colorectal cancer at a young age compared to earlier generations, suggesting that factors in their early environment or lifestyle, rather than aging or medical screening, are responsible for this trend.

People diagnosed with colorectal cancer before age 50 show different DNA methylation patterns linked to picloram herbicide exposure compared to those diagnosed at age 70 or older, suggesting a possible environmental association with earlier disease onset.

In U.S. counties where more picloram pesticide is used, there is a higher rate of colorectal cancer diagnosed in people under 50, even when accounting for income, education, and exposure to other pesticides.