For people with HIV taking tesamorelin, changes in their growth hormone levels didn't match changes in their trunk muscle thickness or size.
Scientific Claim
Changes in insulin-like growth factor-1 levels did not correlate with changes in trunk muscle density or area in HIV-positive adults receiving tesamorelin.
Original Statement
“Change in IGF-1 was not significantly correlated with change in density or area.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim correctly uses 'did not correlate' to describe the lack of statistical relationship observed in the data, which is appropriate for correlational findings.
Evidence from Studies
Supporting (0)
Contradicting (1)
The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV
The study found that a drug called tesamorelin made HIV patients' trunk muscles bigger and denser, and since this drug is known to increase a hormone called IGF-1, it suggests that IGF-1 changes are linked to muscle improvements — the opposite of what the claim says.