Giving mice both nicotine and a diabetes drug called liraglutide together helps them lose weight by making them eat less and burn more calories.

If you lose weight on a low-calorie diet, you're more likely to keep it off if you combine liraglutide with aerobic exercise, rather than doing just one of those things — the exercise seems to boost how well the medication works over time.

For adults with obesity, taking liraglutide plus metformin helps you lose more weight than just taking metformin — about 4 extra pounds on average over 6 months.