For men over 40 with low testosterone, taking testosterone therapy might raise their risk of irregular heartbeats by more than half, which doctors should take seriously.

73

Pro

0

Against

Evidence from Studies

Supporting (1)

73

Community contributions welcome

73

Long-Term Cardiovascular Safety of Testosterone-Replacement Therapy in Middle-Aged and Older Men: A Meta-analysis of Randomized Controlled Trials

Systematic Review With Meta-Analysis

Human

2025 Nov

This study found that men over 40 with low testosterone who took testosterone therapy had a 53% higher chance of developing irregular heartbeats compared to those who didn’t — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Long-Term Cardiovascular Safety of Testosterone-Replacement Therapy in Middle-Aged and Older Men: A Meta-analysis of Randomized Controlled Trials

Score: 73

DOI: 10.1007/s40256-025-00737-w

Similar Assertions

For men over 40 with low testosterone, taking testosterone therapy doesn't clearly raise or lower the chance of a heart attack — but it might still increase it by up to 28%, so we can't say for sure it's safe.

73

0

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Giving testosterone to older men with low levels doesn’t seem to make their heart problems worse, but it also might slightly increase the risk — so we can’t say for sure if it’s completely safe for the heart.

73

0

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For men with low testosterone, taking testosterone medicine might slightly raise the chance of having an irregular heartbeat, but we’re not sure if that’s actually important for their health.

0

1

79%

Men between 55 and 67 who take testosterone therapy may be 13% less likely to die from heart disease than men who don’t take it, based on a long-term study tracking them for 18 years.

53

0

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Giving men the right amount of testosterone to bring their levels back to normal doesn’t make their heart worse — and might even help their metabolism and blood sugar.

55

0

77%