correlational
Analysis v1
Strong Support

If you lift the same total weight, your quads grow just as much whether you rest 20 seconds or 2 minutes between sets—so you don’t need to feel the burn to build muscle.

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Pro
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Against

Evidence from Studies

Supporting (1)

51

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The study found that whether guys rested 20 seconds or 2 minutes between sets, their thigh muscles grew just as much—as long as they did the same total amount of work. So, you don’t need to feel the burn to build muscle if you do enough reps.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.