mechanistic
Analysis v1
Strong Support
If you take testosterone by mouth, your liver breaks it down before it can do anything in your body, so doctors have to give it as a shot or change its chemical structure so it survives digestion.
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Evidence from Studies
Supporting (1)
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ENDOCRINE HISTORY: The history of discovery, synthesis and development of testosterone for clinical use.
Narrative Review
2019 Jun 1Oral testosterone gets broken down by the liver before it can work, so doctors can't just give it as a pill—they have to use shots or change the molecule so it survives digestion.
Contradicting (0)
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No contradicting evidence found
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