In the United States, men between the ages of 25 and 44 died from early-onset colorectal cancer at a higher rate than women in 2020, with 2.6 deaths per 10,000 men compared to 2.0 per 10,000 women.

Between 1999 and 2020, the number of deaths from colorectal cancer among U.S. adults aged 25 to 44 rose slightly, from 2.1 to 2.6 deaths per 10,000 people, after accounting for changes in age distribution.

Since 2013, the number of new colorectal cancer cases per year has risen by 3% each year among U.S. adults aged 20 to 49, while cases have decreased in older adults.

From 1999 to 2020, Non-Hispanic Black adults in the U.S. died from early-onset colorectal cancer at a higher rate per 10,000 people than any other racial or ethnic group, after accounting for differences in age distribution.

Between 2000 and 2022, the number of deaths from colorectal cancer in people aged 20 to 44 rose slightly each year, while death rates in people aged 45 to 54 stayed about the same, suggesting that younger adults are dying from this cancer at a higher rate than before.

Since 2004, the number of deaths from colorectal cancer has risen by 1% each year among people under 50 in the United States, even as deaths from this cancer have decreased in older adults. This suggests that more younger people are being diagnosed and dying from the disease.