Berberine, a natural compound, helped hamsters with high cholesterol by making their livers produce more receptors that grab bad cholesterol out of the blood—like putting up more trash cans to clean up the streets.

A natural compound called berberine can significantly lower bad cholesterol in hamsters with high cholesterol, and it does this by helping their liver make more of a special protein that pulls cholesterol out of the blood.

Berberine, a natural compound, may help lower bad cholesterol by helping your liver grab more of it from your blood—kind of like turning up a vacuum cleaner that sucks up cholesterol, thanks to how it blocks a protein called PCSK9 and keeps the cholesterol sensors in your liver working longer.

Berberine, a natural compound, helps lower bad cholesterol in mice and hamsters by turning down a protein (HNF1α) that normally tells the liver to make more PCSK9 — when PCSK9 drops, the liver keeps more LDL receptors to mop up cholesterol from the blood.

Berberine, a natural compound, helps your liver cells make more LDL receptors—these are like little doors that pull bad cholesterol out of your blood—by keeping the instructions for making those doors from falling apart, and it needs a specific cell signal (ERK) to do this.

Taking berberine pills may help lower your 'bad' cholesterol and fat in your blood by about 10–20%, which could be good for your heart.