When cells lining blood vessels get stirred up by a protein called TNF-alpha (which happens during inflammation), two natural plant compounds—luteolin and apigenin—can calm them down by blocking a key internal signal (NF-kappa B) that tells the cells to stick to immune cells. This might help reduce swelling and inflammation.

4

Pro

0

Against

Evidence from Studies

Supporting (1)

4

Community contributions welcome

4

Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B.

Cross-Sectional Study

In Vitro

2004 May

Scientists found that two natural compounds, luteolin and apigenin, stop a key inflammation signal (NF-kappa B) from entering the nucleus of blood vessel cells and turning on adhesion molecules — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B.

Score: 4

DOI: 10.1093/JN/134.5.1013

Similar Assertions

When scientists add a stress signal to blood vessel cells in a dish, those cells start making a sticky protein that can cause inflammation—but two natural plant compounds, luteolin and apigenin, stop this from happening, especially at higher doses.

4

0

84%

When scientists add certain plant compounds called luteolin and apigenin to blood vessel cells that are stirred up by an inflammation signal, fewer immune cells stick to them—kind of like stopping sticky notes from clinging. Other similar plant compounds usually don’t help, except for quercetin, which helps a little.

4

0

79%