In liver cells from rats, nitric oxide lasts longer when there's less oxygen around because it doesn't get used up as quickly.

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Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2.

Cohort Study

Animal

2001 Jan 2

The study found that in rat liver cells, nitric oxide lasts longer when there’s less oxygen around, exactly as the claim says — it lives between 0.09 and over 2 seconds depending on oxygen levels.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2.

Score: 12

DOI: 10.1073/pnas.98.1.355

Similar Assertions

When there's oxygen around, nitric oxide breaks down slowly in tissues, which lets it travel farther from blood vessels than if it disappeared at a steady rate. Think of it like a scent that lingers longer so it can spread farther.

12

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75%

Nitric oxide breaks down too fast in the body to be taken as a pill or swallowed—it has to be made inside the body using other substances because it disappears in less than two seconds.

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71%