In people with obesity, fat tissue that processes male hormones differently seems to be linked to having more fat around the waist.

28

Pro

0

Against

Evidence from Studies

Supporting (1)

28

Community contributions welcome

28

Intra‐adipose sex steroid metabolism and body fat distribution in idiopathic human obesity

Cross-Sectional Study

Human

2007 Mar

This study found that in obese people, higher levels of two specific genes (AKR1C2 and AKR1C3) in belly fat are linked to having more fat around the waist — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Intra‐adipose sex steroid metabolism and body fat distribution in idiopathic human obesity

Score: 28

DOI: 10.1111/j.1365-2265.2007.02755.x

Similar Assertions

In people with obesity, the levels of receptors and enzymes for male and female hormones in fat tissue don’t seem to be linked to how much fat they have or where it’s stored.

28

0

73%

In people with obesity, women’s fat tissue under the skin has about 60% more of a specific molecule (IRS1) that helps respond to insulin than men’s, and this difference is real—not just due to chance.

49

0

71%