In pig milk cells, the GPR40 receptor is more important than GPR120 for helping oleic acid make milk fat.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Oleic acid-enriched diet improves maternal lactation performance and neonatal growth through GPR40 and GPR120 signaling pathways

Randomized Controlled Trial

Animal

2025 Dec

The study found that when oleic acid triggers fat production in pig mammary cells, GPR40 is the main switch that turns it on—blocking it cuts fat production by nearly 40%, while blocking GPR120 has a much smaller effect.

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Source Study

Oleic acid-enriched diet improves maternal lactation performance and neonatal growth through GPR40 and GPR120 signaling pathways

Score: 13

DOI: 10.1016/j.jnutbio.2025.110062

Similar Assertions

When scientists blocked one specific receptor (GPR40) in pig milk cells, the cells made about 38% less milk fat from oleic acid — blocking the other receptor (GPR120) had a smaller effect.

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In pig milk-making cells, oleic acid turns on certain fat-handling proteins and helps make more milk fat, and this happens mostly through two specific cell receptors called GPR40 and GPR120.

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87%