In rat veins, a ketone body relaxed different veins at different doses, with arm veins relaxing at lower doses than leg or gut veins.
Scientific Claim
In isolated rat veins, sodium 3-hydroxybutyrate caused concentration-dependent relaxation in femoral, brachial, and mesenteric veins, with brachial veins responding at 1 mM and femoral/mesenteric veins requiring 6 mM for significant relaxation.
Original Statement
“3-OHB also relaxed caudal femoral, profound brachial, and mesenteric veins in a concentration-dependent manner (Fig. 5A–D). Whereas the profound brachial veins relaxed even in response to 1 mM 3-OHB (Fig. 5C), the caudal femoral and mesenteric veins responded significantly only when 3-OHB concentrations were elevated to 6 mM or higher (Fig. 5B, D).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The isolated vein experiments with precise concentration testing support definitive descriptive statements for the model.
Evidence from Studies
Supporting (1)
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility