In mouse skin cells that aren't dividing, a protein called DGUOK helps keep important energy-related genes working properly. If DGUOK is removed, those genes slow down, and the energy factories in...

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Evidence from Studies

Supporting (1)

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Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying

Cohort Study

Animal

2025 Jun 16

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No contradicting evidence found

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Source Study

Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying

Score: 13

DOI: 10.1186/s13619-025-00242-0

Similar Assertions

A specific protein called DGUOK keeps the energy-producing parts of skin cells working properly. If this protein is missing, the cells' energy factories get damaged and start to swell, which messes up their ability to make energy.

91%

Mice that are missing a certain gene have weaker energy production in their skin cells because their mitochondrial genes aren't working as well, especially as their fur starts growing again later in life.

83%