In mouse skin cells that aren't dividing, a protein called DGUOK helps keep important energy-related genes working properly. If DGUOK is removed, those genes slow down, and the energy factories in cells (mitochondria) swell and get damaged.

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Evidence from Studies

Supporting (1)

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Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying

Cohort Study

Animal

2025 Jun 16

The study shows that when a gene called DGUOK is turned off in pigment-producing stem cells in mouse skin, the cells lose their energy genes and stop working properly, which matches the main idea of the claim.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying

Score: 13

DOI: 10.1186/s13619-025-00242-0

Similar Assertions

Mice that are missing a certain gene have weaker energy production in their skin cells because their mitochondrial genes aren't working as well, especially as their fur starts growing again later in life.

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