In the artery walls where plaques burst, the genes that make Th17 and Th1 immune cells were turned way up — showing the immune system was actively working right at the site of damage.

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Pro

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Against

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

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Community contributions welcome

17

Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice

Cohort Study

Animal

2013 Jul

The study found that a type of immune cell (Th17) and its chemical IL-17 are linked to plaque rupture, but it didn’t find evidence that the other immune factor (Th1) is involved, and it didn’t measure the specific genes mentioned in the claim.

Source Study

Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice

Score: 17

DOI: 10.1038/cmi.2013.4

Similar Assertions

When mice with fatty arteries were stressed, the number of a specific type of immune cell called Th17 went up dramatically — but another type, Th1, stayed the same, suggesting Th17 might be special in causing artery damage.

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