In this gel model, the number of cells decreases for two weeks then levels off, while their energy use increases for a week then stabilizes after three weeks.
Scientific Claim
In a collagen-agarose hydrogel model with hydroxyapatite gradients, cell DNA content decreases over 14 days and stabilizes by day 21, while metabolic activity peaks at day 7 and stabilizes by day 21.
Original Statement
“The DNA content of cells decreased until day 14 and then stabilized on day 21 (Figure 10A). The metabolic activity of cells increased until day 7 and decreased by day 14, while it stabilized on day 21 (Figure 10B), indicating that cells were still metabolically active and reached homeostasis on day 14.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The study directly measured DNA content and metabolic activity using standardized assays, so the trends described are factual observations.
Evidence from Studies
Supporting (1)
Triphasic 3D In Vitro Model of Bone-Tendon-Muscle Interfaces to Study Their Regeneration