For boys with a rare brain condition causing early puberty that doesn’t respond well to standard treatment, adding two more medications to their existing one might help slow down the early growth changes and improve their long-term height over time.

In boys with a rare brain condition causing early puberty, a combo treatment might not stop puberty from progressing, even if it lowers some hormones — because they keep growing too fast and their bones mature too quickly.

Some boys with a rare brain condition causing early puberty don't see their testosterone levels drop all the way to normal, even after long-term treatment with a common hormone therapy.

For girls with early puberty who are treated with two hormones (one for puberty and one for growth), the ones who grow more during treatment tend to have started with a lower predicted adult height and more mature bones. How long or how much growth hormone they take doesn’t seem to affect how much they grow.

Giving kids with early puberty a certain medicine doesn't seem to change their blood sugar, cholesterol, thyroid levels, testosterone, or bone strength during treatment.

Girls with early puberty who get a certain hormone treatment tend to have slower bone aging—about 1 year less—compared to girls who don’t get the treatment.