In women with fibromyalgia and healthy women, a 15-minute session of moderate or high-intensity cycling raises IGF-1 levels in the blood by a similar amount, regardless of how much body fat they have.

A 15-minute moderate cycling workout raises levels of insulin-like growth factor-1 (IGF-1) in the blood by about 11 ng/mL in women with fibromyalgia, and the increase is similar to that seen in women without fibromyalgia.

Women with fibromyalgia show the same short-term rise in two specific blood proteins (IGF-1 and IGFBP-3) during exercise as healthy women, even though they exercise at lower intensities.

In women with fibromyalgia, a 15-minute session of moderate exercise raises levels of IGF-1 and IGFBP-3 in the blood without changing markers of inflammation like CRP or IL-8, suggesting these hormonal changes happen without involvement of inflammatory processes.

Women with fibromyalgia report more pain and fatigue during intense exercise than women without the condition, even though both groups show similar rises in a blood protein called IGF-1, suggesting that how the body responds chemically doesn't always match how much discomfort a person feels.

During short bouts of endurance exercise, people with obesity maintain the same levels of bioactive IGF-1 in their blood as lean individuals, even though overall IGF-1 and its binding protein increase less than in lean people.