Lifting weights once can use up a lot of the sugar stored in your thigh muscles, which your body needs for energy during hard exercise.

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Pro

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Against

Evidence from Studies

Supporting (1)

50

Community contributions welcome

50

Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta‐analysis

Systematic Review With Meta-Analysis

Human

2025 Dec

Contradicting (0)

0

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta‐analysis

Score: 50

DOI: 10.14814/phy2.70683

Similar Assertions

After a weightlifting workout, the main leg muscle loses a lot of its stored sugar energy—about 21% on average—which can make you feel tired and affect how well you do in your next workout.

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The longer you spend lifting weights, the more sugar your muscles use up.

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The more sets you do when lifting weights, the more sugar your muscles burn through.

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The longer you lift weights in one session, the more your muscle sugar gets used up—every extra minute burns about 1.3 more units of energy.

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When you lift super heavy weights until you can't do another rep, your muscles use up a lot of their stored sugar (glycogen) to keep going — this shows your body is breaking down that sugar fast to power your workout.

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