Mice on a high-fat diet hold onto more salt because their kidneys are reabsorbing more of it through a specific pathway—this was shown by giving them a water pill and seeing they flushed out way more salt than mice on a low-fat diet.

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Evidence from Studies

Supporting (1)

10

Community contributions welcome

10

Inducible Renal Tubule‐specific Insulin Receptor Knockout Mice Have Decreased NCC‐mediated Sodium Reabsorption and Reduced Sensitivity to Mineralocorticoid‐induced Hypertension in Obesity and Insulin Resistance

Cross-Sectional Study

Animal

The study shows that mice on a high-fat diet retain more sodium through a specific kidney pathway, just like the claim says, and this was tested using the same method.

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No contradicting evidence found

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Source Study

Inducible Renal Tubule‐specific Insulin Receptor Knockout Mice Have Decreased NCC‐mediated Sodium Reabsorption and Reduced Sensitivity to Mineralocorticoid‐induced Hypertension in Obesity and Insulin Resistance

Score: 10

DOI: 10.1096/FASEBJ.30.1_SUPPLEMENT.968.1

Similar Assertions

When scientists turned off insulin's signal in the kidney tubes of obese, insulin-resistant mice, the mice didn't hold onto salt as much — showing that insulin in the kidneys helps control salt balance in obesity.

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When healthy young men eat a lot of salt, their kidneys use the part of the tubule that thiazide drugs target to reabsorb more sodium — so when you give them a thiazide, it works way better at making them pee out salt.

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When people eat a lot of salt, their kidneys use a specific part (the DCT) to reabsorb more sodium — so when you give them a diuretic like hydrochlorothiazide, it works way better at making them pee out salt.

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