Male mice that can't transport creatine properly in their muscles have mitochondria that aren't working efficiently — they're using energy but not making as much usable fuel (ATP), kind of like a car engine that's revving but not moving.

In male mice that can't transport creatine properly, their muscle mitochondria get way bigger, move to the wrong part of the muscle cell, and get damaged inside — like tiny powerplants going haywire.

In male mice that can't transport creatine properly, their muscle cell powerhouses don't handle calcium well when triggered, even though calcium levels look normal at rest.

Male mice that can't transport creatine properly have much weaker muscles — their muscle fibers shrink by over two-thirds and take up less space in the muscle, showing serious damage to fast-moving muscle types.

Male mice that can't transport creatine properly have super weak muscles — their grip gets way worse as they age, and their leg muscles can't produce nearly as much force or power as normal mice.

If you cycle for two hours and don't have creatine in your muscles, your muscle cells' energy powerhouses become less responsive to a key energy signal, which might mean energy can't move as easily without creatine.