Drinking a lot of fruit juice might increase fat in your liver, even if you're not eating too many calories overall.

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Pro

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Against

Evidence from Studies

Supporting (1)

56

Community contributions welcome

56

Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study.

Cross-Sectional Study

Human

2022 May 1

The study found that people who drank more fruit juice had slightly more fat in their liver, even after accounting for how many calories they ate, which supports the idea that fruit juice might increase liver fat.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study.

Score: 56

DOI: 10.2337/dc21-2123

Similar Assertions

Eating fructose from whole fruits doesn’t seem to raise liver fat in middle-aged people, even after accounting for things like how much they eat or how active they are — maybe because the natural package of the fruit protects against any downsides of fructose.

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If you have type 2 diabetes, drinking fruit juice with fructose might affect your liver more than it would for someone without diabetes, possibly leading to more fat building up in the liver.

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Even if you drink fruit juice with lots of fructose, it doesn’t seem to make your body less sensitive to insulin or worsen fatty liver—once you account for how much you eat overall and how active you are.

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Drinking more sugary drinks might increase fat in your liver, especially if you're a middle-aged adult. People who drink the most of these beverages tend to have about 9% more liver fat than those who drink the least, even after accounting for other health and lifestyle differences.

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How much fructose you eat doesn’t seem to affect liver fat in middle-aged adults — it might matter more where the fructose comes from, like fruit versus soda, rather than how much you eat.

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