mechanistic
Analysis v1
Strong Support
A person taking a high dose of a cholesterol-lowering statin drug had kidney tubule problems that went away when they stopped the drug — but came back when they took it again, suggesting the drug might have caused it.
20
0
Evidence from Studies
Supporting (1)
20
Community contributions welcome
20
Renal tubular toxicity of HMG-CoA reductase inhibitors.
Case Report
Human
2004 DecThe study shows that a person had kidney tube problems from a high dose of a cholesterol drug, got better when they stopped it, and got sick again when they took it again—supporting the idea that the drug caused the problem.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.