People who build the most muscle from weight training show increased activity in their muscle cells’ systems that rebuild proteins, use energy during exercise, and fix damaged proteins.
Scientific Claim
High responders to resistance training show upregulation of molecular pathways related to protein turnover, metabolic response to training, and protein folding, which are associated with robust muscle growth.
Original Statement
“RNA-Seq showed that high responders' robust hypertrophy was followed by up-regulation of pathways linked with protein turnover metabolism, RT-related metabolic response, and protein-folding biological processes.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The abstract describes observed molecular patterns, not experimental manipulation of pathways, so 'upregulation is associated with' is more accurate than implying causation.
More Accurate Statement
“High responders to resistance training are associated with upregulation of molecular pathways related to protein turnover, metabolic response to training, and protein folding.”
Evidence from Studies
Supporting (1)
Molecular signatures underlying heterogenous hypertrophy responsiveness to resistance training in older men and women: a within-subject design.
People who grew the most muscle after lifting weights had their bodies turn on genes that help build and repair proteins more efficiently, which is exactly what the claim says.