People who eat healthy low-carb or low-fat diets tend to have certain natural chemicals in their bodies that are linked to better heart health—like more of one helpful compound and less of another—and it might be because these diets work in similar ways inside the body.

59

Pro

0

Against

Evidence from Studies

Supporting (1)

59

Community contributions welcome

59

Effect of Low-Carbohydrate and Low-Fat Diets on Metabolomic Indices and Coronary Heart Disease in U.S. Individuals.

Cohort Study

Human

2026 Jan 30

This study found that people who ate healthy low-carb and low-fat diets had better blood chemicals—like more 3-indolepropionic acid and less valine—which are linked to a healthier heart. So yes, the diets help in the same way the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effect of Low-Carbohydrate and Low-Fat Diets on Metabolomic Indices and Coronary Heart Disease in U.S. Individuals.

Score: 59

DOI: 10.1016/j.jacc.2025.12.038

Similar Assertions

People who eat healthy diets low in carbs and fat tend to have certain chemicals in their blood—more of one called 3-indolepropionic acid and less of another called valine—and these chemicals might be linked to a lower risk of heart disease.

52

0

92%

People who eat healthy low-carb or low-fat diets tend to have certain chemicals in their blood—like more 3-indolepropionic acid and less valine—that are connected to better heart health, such as lower bad fats, higher good cholesterol, and less body inflammation.

59

0

91%

People who eat healthy low-carb or low-fat diets tend to have certain natural body chemicals that are linked to better heart health—like lower bad fats and higher good cholesterol.

59

0

91%