Even when you train one leg differently from the other, both legs tend to grow muscle in similar ways — which means your body’s natural biology, not the workout itself, is what really controls muscle growth.

Individual hypertrophic responses to resistance training are highly variable across muscle groups and are not consistently correlated between upper and lower body musculature.

Individual hypertrophic responsiveness to resistance training exhibits moderate inter-muscle correlation, but a substantial proportion of variability is attributable to non-exercise-specific biological factors.

When people lift weights, how much their muscles grow depends way more on their own body than on the type of workout they do—because even when people switch up their routines, their muscle growth stays pretty much the same.

If you're already used to lifting weights, it doesn't really matter if you change up how heavy you lift, how many reps you do, or how long you rest—your muscles will grow about the same either way.

Some people’s muscles grow a lot with training, others don’t—but if one person’s arms grow, their legs usually grow similarly, meaning your body’s natural response is more important than which muscles you train.