When rats have very high blood sugar (like in a dangerous condition called HHS), their fat cells don’t release as much fat into the blood — and that’s why they don’t make ketones, even though you’d expect them to.

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Evidence from Studies

Supporting (1)

12

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12

Simulated hyperglycemic hyperosmolar syndrome. Impaired insulin and epinephrine effects upon lipolysis in the isolated rat fat cell.

Cohort Study

Animal

1979 Mar

When blood sugar and salt levels are super high (like in a serious diabetic condition), fat cells stop releasing the fatty acids needed to make ketones — so no ketones are made, even when the body should be making them.

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Source Study

Simulated hyperglycemic hyperosmolar syndrome. Impaired insulin and epinephrine effects upon lipolysis in the isolated rat fat cell.

Score: 12

DOI: 10.1172/JCI109316

Similar Assertions

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12

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