Pig blood tests before and after knee surgery showed no big changes in immune cells or platelets, regardless of whether they got a scaffold.
Scientific Claim
In Yucatan minipigs undergoing ACL surgery, systemic white blood cell count, platelet count, and monocyte percentage did not change significantly from preoperative to postoperative measurements (WBC: 11.2±3.29 vs 13.1±3.22 ×10^6/ml, p=0.10; platelets: 340.5±77.1 vs 288.8±79.6 ×10^6/ml, p=0.33; monocytes: 3.1±4.1% vs 1.4±1.0%, p=0.30).
Original Statement
“The mean values of systemic WBC counts at the beginning of the study and after thirteen weeks were 11.2±3.29 and 13.1±3.22 (×106/ml) respectively, a change that was not significant (p=0.10). The mean values of systemic platelet count at the beginning of the study and after thirteen weeks were 340.5±77.1and 288.8±79.6 (×106/ml) respectively, a change that was also not significant (p=0.33). The average monocyte percentage found in WBC pre- and postoperatively was 3.1±4.1% and 1.4±1.0%, respectively, which was not statistically significant (p=0.30).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim accurately reports the pre/post blood parameter changes and p-values without overinterpreting the data.
Evidence from Studies
Supporting (1)
Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament