When male rats eat a lot of sugar and fat, their bodies produce less of certain proteins that help control insulin and blood sugar, which might make it harder for them to manage energy properly.

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Pro

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Against

Evidence from Studies

Supporting (1)

10

Community contributions welcome

10

High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress

Cohort Study

Animal

2016 Dec

The study gave rats lots of sugar and fat, and found that their pancreas and liver stopped making the right proteins to control insulin and blood sugar—exactly what the claim said would happen.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress

Score: 10

DOI: 10.1007/s11010-016-2828-5

Similar Assertions

When male rats eat a lot of sugar, their bodies have a harder time managing blood sugar and fats, just like when they eat a lot of fat — so both kinds of diets might mess up their metabolism in similar ways.

10

0

74%

When the pancreas gets fatty, especially in people whose blood sugar is already high, it doesn’t make enough insulin — like a factory that’s clogged with grease and can’t produce its product properly.

51

0

70%