If you swap out regular sugar or glucose for fructose in your diet but keep the same number of calories, your fasting insulin levels won’t change—whether or not you have diabetes.

44

Pro

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Against

Evidence from Studies

Supporting (1)

44

Community contributions welcome

44

Chronic fructose substitution for glucose or sucrose in food or beverages has little effect on fasting blood glucose, insulin, or triglycerides: a systematic review and meta-analysis.

Systematic Review With Meta-Analysis

Human

2017 Aug

This study looked at what happens when people swap sugar (like table sugar or glucose) for fructose (a different kind of sugar) but keep eating the same number of calories. It found that fasting insulin levels didn’t change at all, which means the claim is correct.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Chronic fructose substitution for glucose or sucrose in food or beverages has little effect on fasting blood glucose, insulin, or triglycerides: a systematic review and meta-analysis.

Score: 44

DOI: 10.3945/ajcn.116.145169

Similar Assertions

If you swap out regular sugar or glucose in your food and drinks for fructose (a different kind of sugar) without changing how many calories you eat, it might slightly reduce your fasting blood sugar by a tiny bit — even if you have diabetes or not.

44

0

86%

If you swap out regular sugar or glucose for fructose in your diet without changing how many calories you eat, it might slightly reduce a type of fat in your blood called triglycerides — which could be a small good thing for your heart and liver.

44

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79%

If you swap out regular sugar or glucose with fructose in your diet without changing how many calories you eat, you might lose a little bit of weight—about 3 pounds—over time.

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0

76%

If you eat a lot of fructose—like from sugary drinks—for just 9 days, even without gaining weight or eating more calories overall, your liver becomes less responsive to insulin, which means it keeps making sugar when it shouldn’t.

1

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71%