Scientists confirmed that the supplement delivered propionate to the colon by tracking a special marker in breath tests, with most of it reaching the colon after gas production started.
Scientific Claim
Inulin-propionate ester delivery to the colon was confirmed by stable isotope methodology, with >80% of the propionate load released in the colon coincident with or after a rise in breath H2.
Source Excerpt
“Stable isotope methodology revealed that >80% of the propionate load from the inulin-propionate ester is released in the colon coincident with or after a rise in breath H2. This would suggest that only a relatively small amount of the esterified propionate is released and absorbed in the small intestine.”
Evidence from Studies
Supporting Studies
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
The study used stable isotope methodology to track propionate release, showing that the majority of the propionate was delivered to the colon as intended. This is a methodological confirmation of the delivery system's effectiveness.