Scientists found MOTS-c in the blood of humans and mice, and when they fasted, the levels dropped—hinting it might be a hormone that tells the body how to use energy.
Scientific Claim
In human and rodent plasma, MOTS-c peptide is detectable via ELISA, and its levels are lower in fasting states, suggesting it may function as a circulating signaling molecule with metabolic regulatory potential.
Original Statement
“MOTS-c was detected in various tissues in mice and rats... as well as in circulation in human and rodent plasma as determined with a MOTS-c specific ELISA... fasting lowered endogenous expression of MOTS-c... in plasma.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The detection of MOTS-c in plasma and its fasting-induced reduction are observational and descriptive. The language used is appropriate for the evidence.
Evidence from Studies
Supporting (1)
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
This study found that a tiny molecule from mitochondria, called MOTS-c, helps control metabolism and insulin in mice, suggesting it acts like a hormone that travels in the blood—just like the claim says.