If you're taking statins for cholesterol, the chance of getting a serious muscle problem like rhabdomyolysis is less than 1 in 1,000 — so it's very rare.

What we've found so far suggests that serious muscle damage from statins is very rare. Based on the evidence we’ve reviewed, the chance of developing a severe muscle problem like rhabdomyolysis while taking statins is less than 1 in 1,000 [1]. Our analysis of the available research shows that while statins are commonly prescribed for cholesterol management, serious muscle-related side effects do not appear to be widespread. The one assertion we examined indicates that rhabdomyolysis — a condition where muscle tissue breaks down and can lead to kidney damage — occurs so infrequently that it’s considered uncommon [1]. This means most people taking statins are unlikely to experience this level of muscle damage. However, our current analysis is based on limited evidence — only one supporting assertion and no studies or claims that refute it. Because of this, we can’t yet say how often milder muscle symptoms (like aches or weakness) occur, or whether certain people may be at higher risk. We also can’t determine if factors like dosage, age, or other medications change the likelihood of serious muscle issues. The evidence we’ve reviewed leans toward serious muscle damage being a rare event, but we don’t have enough data to fully understand the range of risks for different individuals. As we gather more information, our understanding may change. Practical takeaway: If you're on a statin, serious muscle damage is unlikely, but it’s still important to talk to your doctor if you notice unexplained muscle pain, tenderness, or weakness — especially if accompanied by dark urine.